Anti-AANAT 抗体 (ab3506)

Anti-AANAT antibody
AANAT 一次抗体 製品一覧

Rabbit polyclonal to AANAT

Rabbit

交差種: Rat
交差が予測される動物種: Mouse, Hamster, Human, Chimpanzee, Rhesus monkey

Synthetic peptide corresponding to Rat AANAT aa 195-205 (C terminal).
Sequence:

CHTFLRRNSGC

(Peptide available as ab5004)

Run BLAST with Run BLAST with

Liquid

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 99% PBS

Immunogen affinity purified

Total anti-C-terminal AA-NAT-specific IgG was affinity purified on resin-coupled non-phosphopeptide. Phospho-specific carboxy-terminal IgG was subsequently isolated on resin-coupled phosphopeptide.

Pineal gland serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT) is an ~23 kDa protein which is the rate-limiting enzyme in melatonin synthesis. Melatonin serves as the hormonal signal of the daily light/dark cycle, or body clock. The nocturnal oscillation in enzyme activity ranges by 10- to 100-fold depending on species among vertebrates. Studies have shown that AA-NAT is regulated by cAMP at both the mRNA and protein levels. AA-NAT has putative protein kinase A (PKA) sites at Thr29 and Ser206. Phosphorylation of AA-NAT at these residues might play a role in protein inactivation via proteasome-dependent degradation.

ポリクローナル

IgG

• Neuroscience
• Neurotransmitter
• Biogenic Amines
• Serotonin / 5HT

• Neuroscience
• Neurology process
• Circadian Rhythm
• Hormones

• Cancer
• Cancer Metabolism
• Metabolic signaling pathway
• Hormone biosynthesis

• Metabolism
• Pathways and Processes
• Endocrine metabolism
• Hormone biosynthesis

• Metabolism
• Types of disease
• Cancer

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