A 769662, AMP-activated protein kinase activator (ab120335)

製品の概要

  • 製品名

    A 769662, AMP-activated protein kinase activator
  • 製品の詳細

    AMP-activated protein kinase activator
  • 生理活性の詳細

    Potent, reversible activator of AMP-activated protein kinase (AMPK) (EC50 = 0.8 μM). Directly activates native rat AMPK by mimicking the effects of AMP - it activates AMPK both allosterically and by inhibiting dephosphorylation of AMPK. Shown to inhibit Na+-K+-ATPase at higher concentrations (IC50 = 57 μM) . Inhibits differentiation of adipocytes.
  • 精製度

    > 99%
  • CAS 番号

    844499-71-4
  • 構造式

    Chemical Structure

製品の特性

  • 体系名

    6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
  • 分子量

    360.39
  • 分子式

    C20H12N2O3S
  • PubChem 登録番号

    54708532
  • 保存方法

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性

    Soluble in DMSO to 100 mM and in ethanol to 25 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記

    Oc1ccccc1c2ccc(cc2)c4csc3NC(=O)C(C#N)=C(O)c34
  • 由来

    Synthetic

  • 研究分野

参考文献

This product has been referenced in:

  • Soto-Acosta R  et al. DENV up-regulates the HMG-CoA reductase activity through the impairment of AMPK phosphorylation: A potential antiviral target. PLoS Pathog 13:e1006257 (2017). Read more (PubMed: 28384260) »
  • Benziane B  et al. AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase. Am J Physiol Cell Physiol 297:C1554-66 (2009). Read more (PubMed: 19828836) »
  • Guigas B  et al. Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators. IUBMB Life 61:18-26 (2009). Read more (PubMed: 18798311) »
  • Göransson O  et al. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J Biol Chem 282:32549-60 (2007). Read more (PubMed: 17855357) »
See all 9 Publications for this product

レビューと Q&A

1-2 of 2 Abreviews or Q&A

AMPK

Excellent
Abreviews
AMPK activation in HEK-293 cells. We used a dose on 10uM and 100uM to treat the cells. pAMPK showed a maximal increase at 100uM dose.

Abcam user community

Verified customer

投稿 Sep 05 2018

Answer

Thank you for contacting us.

Ideally the reconstituted A769662 will be fully active for one month at -20C as given in the datasheet. I am sorry we have not done the stability test at -80C so we will not be able confirm it. There are however some vendors who claim that the reconstituted product will be stable for 6-24 months so as Abcam guarantee this product for 6 month so you can use the product again and again by storing it at -20C at least for 6 months.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Free Rabbit monoclonal antibody with any purchase of a primary antibody, while stocks last! Quote “RABMAB-XBSMG” in your next primary antibody order. For more information, visit the following link: https://www.abcam.com/index.html?pageconfig=resource&rid=15447

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