製品の概要

  • 製品名

    A-412997 dihydrochloride, D4 agonist
  • 製品の詳細

    Highly selective D4 agonist
  • 生理活性の詳細

    Highly selective dopamine D4 receptor agonist at rat D4 and human D4.4 receptors (Ki values are 12.1 and 7.9 nM, respectively). Potent, full agonist at rat dopamine D4 receptors (EC50 = 28.4 nM). Superior selectivity profile to PD168077 (ab120568) and CP226269. No affinity for other dopamine receptors (Ki > 1 μM). Able to rapidly cross the blood-brain barrier following systemic administration.
  • 精製度

    > 98%
  • CAS 番号

    630116-49-3
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Woolley ML  et al. Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat. Behav Pharmacol 19:765-76 (2008). Read more (PubMed: 19020411) »
  • Browman KE  et al. A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats. Pharmacol Biochem Behav 82:148-55 (2005). Read more (PubMed: 16154186) »
  • Moreland RB  et al. A-412997 is a selective dopamine D4 receptor agonist in rats. Pharmacol Biochem Behav 82:140-7 (2005). Read more (PubMed: 16153699) »

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