Anti-XPG 抗体 (ab64931)
Key features and details
- Rabbit polyclonal to XPG
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
-
製品名
Anti-XPG antibody
XPG 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to XPG -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide derived from an internal sequence within Human XPG.
-
ポジティブ・コントロール
- Extracts from K562 cells
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Without Mg2+ and Ca2+ -
Concentration information loading...
-
精製度
Immunogen affinity purified -
特記事項(精製)
ab64931 was affinity-purified from rabbit antiserum by affinity-chromatography using an epitope-specific immunogen. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab64931の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB | (1) |
1/500 - 1/1000. Detects a band of approximately 130 kDa (predicted molecular weight: 133 kDa).
|
特記事項 |
---|
WB
1/500 - 1/1000. Detects a band of approximately 130 kDa (predicted molecular weight: 133 kDa). |
ターゲット情報
-
機能
Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too. -
関連疾患
Defects in ERCC5 are the cause of xeroderma pigmentosum complementation group G (XP-G) [MIM:278780]; also known as xeroderma pigmentosum VII (XP7). Xeroderma pigmentosum is an autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Some XP-G patients present features of Cockayne syndrome, including dwarfism, sensorineural deafness, microcephaly, mental retardation, pigmentary retinopathy, ataxia, decreased nerve conduction velocities. -
配列類似性
Belongs to the XPG/RAD2 endonuclease family. XPG subfamily. -
細胞内局在
Nucleus. - Information by UniProt
-
参照データベース
- Entrez Gene: 2073 Human
- Omim: 133530 Human
- SwissProt: P28715 Human
- Unigene: 258429 Human
-
別名
- COFS 3 antibody
- COFS3 antibody
- DNA excision repair protein ERCC 5 antibody
see all
画像
-
All lanes : Anti-XPG antibody (ab64931) at 1/500 dilution
Lane 1 : Extracts from K562 cells
Lane 2 : Extracts from K562 cells with immunising peptide at 10 µg
Lysates/proteins at 30 µg per lane.
Predicted band size: 133 kDa
Observed band size: 130 kDa why is the actual band size different from the predicted?
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (1)
ab64931 は 1 報の論文で使用されています。
- Gaddameedhi S et al. Similar nucleotide excision repair capacity in melanocytes and melanoma cells. Cancer Res 70:4922-30 (2010). WB ; Human . PubMed: 20501836