Anti-Shoc2 / Sur8 抗体 (ab106430)
Key features and details
- Rabbit polyclonal to Shoc2 / Sur8
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-Shoc2 / Sur8 antibody
Shoc2 / Sur8 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Shoc2 / Sur8 -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Human -
免疫原
A 21 amino acid peptide near the N terminus of Human Shoc2/ Sur8 (NP_031399).
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ポジティブ・コントロール
- Jurkat cell lysate; Human spleen tissue
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab106430の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 65 kDa.
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IHC-P |
Use a concentration of 5 µg/ml.
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特記事項 |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 65 kDa. |
IHC-P
Use a concentration of 5 µg/ml. |
ターゲット情報
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機能
Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. -
関連疾患
Defects in SHOC2 are the cause of Noonan syndrome-like with loose anagen hair (NSLAH) [MIM:607721]. NSLAH children display macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck and pectus anomalies. Affected subjects also have easily pluckable, sparse, thin and slow-growing hair. -
配列類似性
Belongs to the SHOC2 family.
Contains 20 LRR (leucine-rich) repeats. -
細胞内局在
Cytoplasm. Nucleus. Translocates from cytoplasm to nucleus upon growth factor stimulation. - Information by UniProt
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参照データベース
- Entrez Gene: 8036 Human
- Omim: 602775 Human
- SwissProt: Q9UQ13 Human
- Unigene: 104315 Human
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別名
- KIAA0862 antibody
- Leucine-rich repeat protein SHOC-2 antibody
- Protein soc-2 homolog antibody
see all
画像
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Lane 1 : Anti-Shoc2 / Sur8 antibody (ab106430) at 1 µg/ml
Lane 2 : Anti-Shoc2 / Sur8 antibody (ab106430) at 2 µg/ml
All lanes : Jurkat cell lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 65 kDa -
ab106430, at 5 µg/ml, staining Shoc2 / Sur8 in paraffin embedded Human spleen tissue by Immunohistochemistry.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab106430 は 3 報の論文で使用されています。
- McBrearty N et al. Short chain fatty acids delay the development of hepatocellular carcinoma in HBx transgenic mice. Neoplasia 23:529-538 (2021). PubMed: 33945993
- Xie CM et al. The FBXW7-SHOC2-Raptor Axis Controls the Cross-Talks between the RAS-ERK and mTORC1 Signaling Pathways. Cell Rep 26:3037-3050.e4 (2019). PubMed: 30865892
- Yen I et al. Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors. Cancer Cell 34:611-625.e7 (2018). PubMed: 30300582