SB431542, ALK inhibitor (ab120163)
Key features and details
- ALK inhibitor
- CAS Number: 301836-41-9
- Soluble in DMSO to 100 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
SB431542, ALK inhibitor -
製品の詳細
ALK inhibitor -
生理活性の詳細
Potent and selective inhibitor of Activin Like Kinase. Inhibits ALK 4, 5 (IC50 = 94 nM), and 7. 3D Growth matrix component; also component of brain and blood vessel organoid differentiation media.
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CAS 番号
301836-41-9 -
構造式
製品の特性
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体系名
4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide -
分子量
384.39 -
分子式
C22H16N4O3 -
PubChem 登録番号
4521392 -
保存方法
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM and in ethanol to 10 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
NC(=O)c1ccc(cc1)c3nc(c2ccccn2)c(n3)c4ccc5OCOc5c4 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (39)
ab120163 は 39 報の論文で使用されています。
- Brazane M et al. The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance. Life Sci Alliance 6:N/A (2023). PubMed: 36720500
- Li Z et al. Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation. Nat Commun 14:2157 (2023). PubMed: 37061531
- Deng S et al. Recruitment of regulatory T cells with rCCL17 promotes M2 microglia/macrophage polarization through TGFβ/TGFβR/Smad2/3 pathway in a mouse model of intracerebral hemorrhage. Exp Neurol 367:114451 (2023). PubMed: 37257716
- Shabani K et al. The temporal balance between self-renewal and differentiation of human neural stem cells requires the amyloid precursor protein. Sci Adv 9:eadd5002 (2023). PubMed: 37327344
- Riesenberg S et al. Efficient high-precision homology-directed repair-dependent genome editing by HDRobust. Nat Methods 20:1388-1399 (2023). PubMed: 37474806