製品名Recombinant mouse PDE10A protein
PDE10A タンパク質・ペプチド 製品一覧
タンパク質長Full length protein
由来Baculovirus infected Sf9 cells
Our Abpromise guarantee covers the use of ab79743 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
生理活性Specific Activity: 599 pmol/min/µg.
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Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
Constituents: 0.0462% DTT, 0.395% Tris HCl, 0.05% Tween, 50% Glycerol, 0.58% Sodium chloride
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- 5''-cyclic phosphodiesterase 10A
- cAMP and cAMP inhibited cGMP 3'5' cyclic phosphodiesterase 10A
- cAMP and cAMP-inhibited cGMP 3''
機能Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.
組織特異性Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
パスウェイPurine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1.
配列類似性Belongs to the cyclic nucleotide phosphodiesterase family.
Contains 2 GAF domains.
ドメインThe tandem GAF domains bind cAMP, and regulate enzyme activity. The binding of cAMP stimulates enzyme activity.
Composed of a C-terminal catalytic domain containing two divalent metal sites and an N-terminal regulatory domain which contains one cyclic nucleotide-binding region.
細胞内局在Cytoplasm. Located mostly to soluble cellular fractions.
- Information by UniProt
ab79743 has not yet been referenced specifically in any publications.