製品名Recombinant Human Tau383 protein
タンパク質長Full length protein
領域1 to 383
Our Abpromise guarantee covers the use of ab84766 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 25% Glycerol, 0.87% Sodium chloride
関連性Tau383 is a memeber of the family of neuronal microtubule-associated proteins. Tau promotes assembly and stabilizes neuronal microtubules under normal physiological conditions, but under pathological conditions can also undergo modifications such as hyperphosphorylation, that can result in the generation of aberrant aggregates such as found in neurofibrillary tangles in Alzheimer's disease. Six isoforms have been found that differ from each other in having either 3 or 4 binding repeats (R) of 31-32 amino acids, and from zero to 3 amino terminal inserts (N) of 29 amino acids each.
細胞内局在Cytoplasm; cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm; cytoskeleton. Cell projection; axon. Note: Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components
ab84766 has not yet been referenced specifically in any publications.