Anti-PPAR alpha 抗体 (ab227074)
Key features and details
- Rabbit polyclonal to PPAR alpha
- Suitable for: WB
- Reacts with: Rat, Human
- Isotype: IgG
製品の概要
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製品名
Anti-PPAR alpha antibody
PPAR alpha 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to PPAR alpha -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Rat, Human
交差が予測される動物種: Dog, Pig, Rhesus monkey -
免疫原
Recombinant fragment within Human PPAR alpha (N terminal). The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: Q07869 -
ポジティブ・コントロール
- ChIP: HepG2 chromatin extract. WB: Rat primary hepatocyte lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.00
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
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Related Products
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab227074の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB | (1) |
1/500 - 1/3000. Predicted molecular weight: 52 kDa.
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特記事項 |
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WB
1/500 - 1/3000. Predicted molecular weight: 52 kDa. |
ターゲット情報
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機能
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. -
組織特異性
Skeletal muscle, liver, heart and kidney. -
配列類似性
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain. -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 403654 Dog
- Entrez Gene: 5465 Human
- Entrez Gene: 397239 Pig
- Entrez Gene: 25747 Rat
- Entrez Gene: 613250 Rhesus monkey
- Omim: 170998 Human
- SwissProt: Q95N78 Dog
- SwissProt: Q07869 Human
see all -
別名
- hPPAR antibody
- MGC2237 antibody
- MGC2452 antibody
see all
画像
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (10)
ab227074 は 10 報の論文で使用されています。
- Kukal S et al. Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPARα-Dependent Mechanism in Human Brain Endothelial Cells. Mol Pharmacol 103:145-157 (2023). PubMed: 36414374
- Wu S et al. Interplay between hypertriglyceridemia and acute promyelocytic leukemia mediated by the cooperation of peroxisome proliferator-activated receptor-α with the PML/RAR α fusion protein on super-enhancers. Haematologica 107:2589-2600 (2022). PubMed: 35546300
- Scisciola L et al. The pivotal role of miRNA-21 in myocardial metabolic flexibility in response to short- and long-term high glucose treatment: Evidence in human cardiomyocyte cell line. Diabetes Res Clin Pract 191:110066 (2022). PubMed: 36058441
- Ceja-Galicia ZA et al. Therapeutic Effect of Curcumin on 5/6Nx Hypertriglyceridemia: Association with the Improvement of Renal Mitochondrial β-Oxidation and Lipid Metabolism in Kidney and Liver. Antioxidants (Basel) 11:N/A (2022). PubMed: 36358567
- Wu J et al. Mechanistic Studies and a Retrospective Cohort Study: The Interaction between PPAR Agonists and Immunomodulatory Agents in Multiple Myeloma. Cancers (Basel) 14:N/A (2022). PubMed: 36358696
- Dai M et al. Icariin enhance mild hypothermia-induced neuroprotection via inhibiting the activation of NF-?B in experimental ischemic stroke. Metab Brain Dis N/A:N/A (2021). PubMed: 33978900
- Murphy SA et al. PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2. Nat Commun 12:1648 (2021). PubMed: 33712605
- Li J et al. Angiotensin II-induced muscle atrophy via PPAR? suppression is mediated by miR-29b. Mol Ther Nucleic Acids 23:743-756 (2021). PubMed: 33614226
- Mishra S et al. Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice. J Clin Invest 131:N/A (2021). PubMed: 34618683
- Wang C et al. CTRP13 Preserves Endothelial Function by Targeting GTP Cyclohydrolase 1 in Diabetes. Diabetes 69:99-111 (2020). PubMed: 31676569