LY 367385, mGlu1a antagonist (ab120067)
Key features and details
- mGlu1a antagonist
- CAS Number: 198419-91-9
- Soluble in 1.1 eq. NaOH to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
LY 367385, mGlu1a antagonist -
製品の詳細
mGlu1a antagonist -
生理活性の詳細
Potent, selective mGlu1a antagonist. Neuroprotective and anticonvulsant in vivo.
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CAS 番号
198419-91-9 -
構造式
製品の特性
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体系名
(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid -
分子量
209.20 -
分子式
C10H11NO4 -
PubChem 登録番号
5311261 -
保存方法
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in 1.1 eq. NaOH to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Cc1cc(ccc1[C@H](N)C(=O)O)C(=O)O -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (12)
ab120067 は 12 報の論文で使用されています。
- Wong NF & Xu-Friedman MA Induction of Activity-Dependent Plasticity at Auditory Nerve Synapses. J Neurosci 42:6211-6220 (2022). PubMed: 35790402
- Robin LM et al. Astroglial CB1 Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory. Neuron 98:935-944.e5 (2018). PubMed: 29779943
- Colavita M et al. Layer-specific potentiation of network GABAergic inhibition in the CA1 area of the hippocampus. Sci Rep 6:28454 (2016). PubMed: 27345695
- Eng AG et al. Transduction of group I mGluR-mediated synaptic plasticity by ß-arrestin2 signalling. Nat Commun 7:13571 (2016). PubMed: 27886171
- Bragina L et al. Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals. Front Cell Neurosci 9:345 (2015). PubMed: 26388733