製品の概要

  • 製品名
    Anti-Fas antibody, prediluted
    Fas 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Fas, prediluted
  • 由来種
    Rabbit
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide within Human Fas aa 300 to the C-terminus (C terminal). The exact sequence is proprietary.
    Database link: P25445

  • ポジティブ・コントロール
    • Small intestine.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab27091 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報
    IHC-P: Use neat for 10 minutes at room temperature. Antigen retrieval is not essential but boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 minutes followed by cooling at RT for 20 minutes may optimise staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
    • 組織特異性
      Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
    • 関連疾患
      Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
    • 配列類似性
      Contains 1 death domain.
      Contains 3 TNFR-Cys repeats.
    • ドメイン
      Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.
    • 細胞内局在
      Secreted and Cell membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • ALPS 1A antibody
      • ALPS1A antibody
      • APO 1 antibody
      • Apo 1 antigen antibody
      • APO 1 cell surface antigen antibody
      • Apo-1 antigen antibody
      • APO1 antibody
      • Apo1 antigen antibody
      • APO1 cell surface antigen antibody
      • Apoptosis antigen 1 antibody
      • Apoptosis mediating surface antigen FAS antibody
      • Apoptosis-mediating surface antigen FAS antibody
      • APT 1 antibody
      • APT1 antibody
      • CD 95 antibody
      • CD 95 antigen antibody
      • CD95 antibody
      • CD95 antigen antibody
      • Delta Fas antibody
      • Delta Fas/APO 1/CD95 antibody
      • Delta Fas/APO1/CD95 antibody
      • Fas (TNF receptor superfamily, member 6) antibody
      • FAS 1 antibody
      • FAS 827dupA antibody
      • Fas AMA antibody
      • Fas antibody
      • FAS Antigen antibody
      • Fas cell surface death receptor antibody
      • FAS1 antibody
      • FASLG receptor antibody
      • FASTM antibody
      • sFAS antibody
      • Surface antigen APO1 antibody
      • TNF receptor superfamily, member 6 antibody
      • TNFRSF 6 antibody
      • TNFRSF6 antibody
      • TNR6_HUMAN antibody
      • Tumor necrosis factor receptor superfamily member 6 antibody
      see all

    画像

    • Human small intestine stained with Anti-CD95 antibody

    参考文献

    ab27091 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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