Rabbit monoclonal [EPR5635] to DBF4
Synthetic peptide corresponding to residues in Human DBF4 protein (Q9UBU7).
PC-3, Jurkat, SW480, and HepG2 cell lysates.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab ® patents
This product is a recombinant rabbit monoclonal antibody.
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Preservative: 0.05% Sodium azide Constituents: 40% Glycerol, 9.85% Tris glycine, 50% Tissue culture supernatant
Tissue culture supernatant
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/10000 - 1/50000. Predicted molecular weight: 77 kDa.
Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.
Highly expressed in testis and thymus. Expressed also in most cancer cells lines.
Contains 2 BRCT domains.
Contains 1 DBF4-type zinc finger.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Information by UniProt
Activator of S phase kinase antibody
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"