Anti-Angiotensin Converting Enzyme 1 抗体 (ab216476)
Key features and details
- Rabbit polyclonal to Angiotensin Converting Enzyme 1
- Suitable for: IHC-P, WB
- Reacts with: Mouse, Rat
- Isotype: IgG
製品の概要
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製品名
Anti-Angiotensin Converting Enzyme 1 antibody
Angiotensin Converting Enzyme 1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Angiotensin Converting Enzyme 1 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-P, WBmore details -
種交差性
交差種: Mouse, Rat
交差が予測される動物種: Cat, Human -
免疫原
Synthetic peptide within Human Angiotensin Converting Enzyme 1 aa 800-900 conjugated to keyhole limpet haemocyanin. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: P12821 -
ポジティブ・コントロール
- IHC-P: Rat pancreas tissue. WB: Mouse lung, liver and adrenal lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA, 48.98% TBS, 1X -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab216476の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
1/100 - 1/500.
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WB | (3) |
1/100 - 1/1000. Predicted molecular weight: 150 kDa.
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特記事項 |
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IHC-P
1/100 - 1/500. |
WB
1/100 - 1/1000. Predicted molecular weight: 150 kDa. |
ターゲット情報
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機能
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. -
組織特異性
Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis. -
関連疾患
Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Note=The disease is caused by mutations affecting the gene represented in this entry.
Microvascular complications of diabetes 3 (MVCD3) [MIM:612624]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Intracerebral hemorrhage (ICH) [MIM:614519]: A pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. -
配列類似性
Belongs to the peptidase M2 family. -
翻訳後修飾
Phosphorylated by CK2 on Ser-1299; which allows membrane retention. -
細胞内局在
Secreted and Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 101094061 Cat
- Entrez Gene: 1636 Human
- Entrez Gene: 11421 Mouse
- Entrez Gene: 24310 Rat
- Omim: 106180 Human
- SwissProt: P12821 Human
- SwissProt: P09470 Mouse
- SwissProt: P47820 Rat
see all -
別名
- ACE 1 antibody
- ACE antibody
- ACE T antibody
see all
画像
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Immunohistochemical analysis of formalin-fixed paraffin-embedded rat pancreas tissue sections labeling Angiotensin Converting Enzyme 1 with ab216476 at a 1/200 dilution. DAB staining.
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All lanes : Anti-Angiotensin Converting Enzyme 1 antibody (ab216476) at 1/300 dilution
Lane 1 : Mouse lung lysates
Lane 2 : Mouse liver lysates
Lane 3 : Mouse adrenal lysates
Secondary
All lanes : Goat anti-rabbit IgG (H+L), HRP conjugated at 1/5000 dilution
Predicted band size: 150 kDa
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab216476 は 2 報の論文で使用されています。
- Man AWC et al. Renal Effects of Fetal Reprogramming With Pentaerythritol Tetranitrate in Spontaneously Hypertensive Rats. Front Pharmacol 11:454 (2020). PubMed: 32410988
- Zhu Y et al. The Effect and Mechanism of Chinese Herbal Formula Sini Tang in Heart Failure after Myocardial Infarction in Rats. Evid Based Complement Alternat Med 2018:5629342 (2018). PubMed: 30050591