Anti-AKR1A1 抗体 (ab125878)
Key features and details
- Rabbit polyclonal to AKR1A1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-AKR1A1 antibody
AKR1A1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to AKR1A1 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Rat, Cow, Pig -
免疫原
Recombinant fragment, corresponding to amino acids 1 - 131 of Human AKR1A1 (P14550).
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ポジティブ・コントロール
- A549 whole cell lysate HepG2 whole cell lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab125878の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 37 kDa.
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特記事項 |
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WB
1/500 - 1/3000. Predicted molecular weight: 37 kDa. |
ターゲット情報
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機能
Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). -
組織特異性
Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung. -
配列類似性
Belongs to the aldo/keto reductase family. - Information by UniProt
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参照データベース
- Entrez Gene: 618607 Cow
- Entrez Gene: 10327 Human
- Entrez Gene: 396924 Pig
- Entrez Gene: 78959 Rat
- Omim: 103830 Human
- SwissProt: Q3ZCJ2 Cow
- SwissProt: P14550 Human
- SwissProt: P50578 Pig
see all -
別名
- AK1A1_HUMAN antibody
- Akr1a1 antibody
- Alcohol dehydrogenase [NADP+] antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab125878 は 1 報の論文で使用されています。
- Mishra P et al. ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming. J Clin Invest 128:323-340 (2018). PubMed: 29202474