5-Azacytidine, DNMT1 inhibitor (ab142744)
- データシート
- 文献 (1)
製品の概要
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製品名
5-Azacytidine, DNMT1 inhibitor -
製品の詳細
Potent DNMT1 inhibitor. Induces DNA hypomethylation. -
別名
- 5-AzadCyD
- Dacogen
- NSC 102816
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生理活性の詳細
Potent DNA methyltransferase 1 (DNMT1) inhibitor (IC50 = 0.2 μM). Incorporated into DNA, inhibits DNMT1 activity to induce DNA hypomethylation. Interferes with protein synthesis. Shows anti-metabolic and anti-cancer activities in vitro. Active in vivo. -
精製度
> 98% -
CAS 番号
320-67-2 -
構造式
製品の特性
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体系名
4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one -
分子量
244.21 -
分子式
C8H12N4O5 -
PubChem 登録番号
9444 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 50 mM and in DMSO to 100 mM -
使用に関する注意
Unstable; make up solutions fresh and use immediately.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
C1=NC(=NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N -
由来
Synthetic
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研究分野
参考文献
This product has been referenced in:
- Shin DY et al. Decitabine, a DNA methyltransferase inhibitor, induces apoptosis in human leukemia cells through intracellular reactive oxygen species generation. Int J Oncol 41:910-8 (2012). Read more (PubMed: 22767021) »
- Rodríguez-Reyes R & Morales-Ramírez P The in vivo induction of sister chromatid exchange by the demethylating agent 5-aza-2'-deoxycytidine. Mutagenesis 26:551-4 (2011). Read more (PubMed: 21454325) »
- Liu QY et al. Decitabine, independent of apoptosis, exerts its cytotoxic effects on cell growth in melanoma cells. Environ Toxicol Pharmacol 32:423-9 (2011). Read more (PubMed: 22004962) »
- Cortvrindt R et al. 5-Azacytidine and 5-aza-2'-deoxycytidine behave as different antineoplastic agents in B16 melanoma. Br J Cancer 56:261-5 (1987). Read more (PubMed: 2444244) »
