5-Azacytidine, DNMT1 inhibitor (ab142744)
Key features and details
- Potent DNMT1 inhibitor. Induces DNA hypomethylation.
- CAS Number: 320-67-2
- Purity: > 98%
- Soluble in water to 50 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
5-Azacytidine, DNMT1 inhibitor -
製品の詳細
Potent DNMT1 inhibitor. Induces DNA hypomethylation. -
別名
- 5-AzadCyD
- Dacogen
- NSC 102816
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精製度
> 98% -
CAS 番号
320-67-2 -
構造式
製品の特性
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体系名
4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one -
分子量
244.21 -
分子式
C8H12N4O5 -
PubChem 登録番号
9444 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 50 mM and in DMSO to 100 mM -
使用に関する注意
Unstable; make up solutions fresh and use immediately.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
C1=NC(=NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N -
由来
Synthetic
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研究分野
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (9)
ab142744 は 9 報の論文で使用されています。
- Mainwaring OJ et al. ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors. Nat Commun 14:1221 (2023). PubMed: 36869047
- Jiang Y et al. Methyl-cpg-binding Domain Protein 2 Silencing Inhibits Th17 Differentiation of CD4+T cells Induced by Ovalbumin. Iran J Immunol 20:45-56 (2023). PubMed: 36932919
- Cossec JC et al. Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures. Cell Rep 42:112380 (2023). PubMed: 37061916
- Nam H et al. Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα. Nat Commun 13:1972 (2022). PubMed: 35418126
- Schwenzer H et al. LARP1 isoform expression in human cancer cell lines. RNA Biol 18:237-247 (2021). PubMed: 32286153
- Alarcón MA et al. The Reprimo-Like Gene Is an Epigenetic-Mediated Tumor Suppressor and a Candidate Biomarker for the Non-Invasive Detection of Gastric Cancer. Int J Mol Sci 21:N/A (2020). PubMed: 33322837
- Chen J et al. 5-Aza-CdR Regulates RASSF1A By Inhibiting DNMT1 To Affect Colon Cancer Cell Proliferation, Migration And Apoptosis. Cancer Manag Res 11:9517-9528 (2019). PubMed: 31807076
- Fort RS et al. Nc886 is epigenetically repressed in prostate cancer and acts as a tumor suppressor through the inhibition of cell growth. BMC Cancer 18:127 (2018). PubMed: 29394925
- Jacobs AH The skin in childhood. Hosp Pract 12:91-112 (1977). PubMed: 142744