2-Methoxyestradiol, antitumor and antiangiogenic agent (ab120653)
Key features and details
- Potent antitumor and antiangiogenic agent
- CAS Number: 362-07-2
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
2-Methoxyestradiol, antitumor and antiangiogenic agent -
製品の詳細
Potent antitumor and antiangiogenic agent -
生理活性の詳細
Potent antioxidant. Inhibits angiogenesis in vivo with direct cytotoxic effects seen in vitro. Interacts with endothelial tubulin dynamics and increases the expression of death receptor 5 in endothelial cells. Induces apoptosis by p53 induction via activation of p38/JNK pathways.
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精製度
> 98% -
CAS 番号
362-07-2 -
構造式
製品の特性
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体系名
(17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol -
分子量
302.41 -
分子式
C19H26O3 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Synthetic
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研究分野
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Nitric oxide & oxidative stress
- Antioxidants
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (1)
ab120653 は 1 報の論文で使用されています。
- Liu J et al. CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1a-Mediated Glycolysis. Immunity 50:600-615.e15 (2019). PubMed: 30824325