製品の概要

  • 製品名

    2-Chloro-N6-cyclopentyladenosine (CCPA), A1 agonist
  • 製品の詳細

    Highly potent, selective A1 agonist
  • 別名

    • CCPA
  • 生理活性の詳細

    Highly potent and selective A1 receptor agonist (Ki values are 0.8, 2300 and 42 nM for human A1, A2A and A3 receptors, respectively). Shows >2000-fold selectivity over A2A. Centrally active following systemic administration and anticonvulsive in vivo.
  • 精製度

    > 98%
  • CAS 番号

    37739-05-2
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Monopoli A  et al. Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine. Arzneimittelforschung 44:1305-12 (1994). Read more (PubMed: 7848348) »
  • Lohse MJ  et al. 2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol 337:687-9 (1988). Read more (PubMed: 3216901) »
  • Luszczki JJ  et al. 2-Chloro-N6-cyclopentyladenosine enhances the anticonvulsant action of carbamazepine in the mouse maximal electroshock-induced seizure model. Pharmacol Rep 57:787-94 (0). Read more (PubMed: 16382198) »
See 1 Publication for this product

レビューと Q&A

1-2 of 2 Abreviews or Q&A

Answer

Thank you for contacting us.



The datasheet for this product states that it is soluble in water to 5 mM, this indicates that it should also be soluble in PBS or saline.



Depending on the assay, I would also advise you to double check the literature for similar assays.

This paper dissolved CCPA in 0.9% saline:

http://circ.ahajournals.org/content/101/24/2841.full.pdf



I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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Answer

Thank you for your email last week and for your patience while I have been in touch with the lab about your enquiry.

The compound contains 0.5 moles of water per mole of compound. This equates to 2.38% water by weight.

I hope this informationwill be useful, but please let me know if you have any furtherquestions or if there is anythingelse that we can do for you.

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