製品の概要

  • 製品名

    17beta-Estradiol, Selective agonist of ER receptor
  • 製品の詳細

    Selective agonist of ER receptor
  • 生理活性の詳細

    Selective agonist of ER receptor. Binds to ERα and ERβ receptors (Ki values are 0.13 and 0.12 nM, respectively). Agonist at the GPR30 receptor, activates PI3K.
  • 精製度

    > 99%
  • CAS 番号

    50-28-2
  • 構造式

    Chemical Structure

製品の特性

画像

  • ERα ligands regulate the expression of CLOCK at the transcription level.

    Analysis of CLOCK mRNA levels in MCF-7 cells by real-time PCR. MCF-7 cells were cultured in phenol red free medium and charcoal striped FCS medium for 2 days before being treated with E2 and the expression of CLOCK was then analyzed by real-time PCR.

    E2 = 17beta-Estradiol.

    (From Figure 3A of Xiao et al).

参考文献

This product has been referenced in:

  • Hernández-Fonseca K  et al. Neuroprotective Role of Estradiol against Neuronal Death Induced by Glucose Deprivation in Cultured Rat Hippocampal Neurons. Neuroendocrinology : (2011). Read more (PubMed: 22213775) »
  • Maggiolini M & Picard D The unfolding stories of GPR30, a new membrane-bound estrogen receptor. J Endocrinol 204:105-14 (2010). Read more (PubMed: 19767412) »
  • Thomas P  et al. Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 146:624-32 (2005). Read more (PubMed: 15539556) »
  • Kuiper GG  et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138:863-70 (1997). Read more (PubMed: 9048584) »
See all 9 Publications for this product

レビューと Q&A

Answer

Thank you for contacting us.
We have tested the solubility of this product in our lab and found that it is soluble in DMSO and in ethanol to the limits stated on the datasheet; this product is not soluble in water. Unfortunately, we do not offer a water soluble version of this product, however do offer the synthetic ester and prodrug 17b-estradiol valerate (ab143321).
I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.
-----------------------------------------------------------------------------------------------
Can’t find the antibody you need? Try our Custom RabMAb® services.
Discover More at www.abcam.com/tag/custom%20services

Read More

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

登録