1400W, iNOS inhibitor (ab120165)
Key features and details
- Selective iNOS inhibitor
- CAS Number: 214358-33-5
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
1400W, iNOS inhibitor -
製品の詳細
Selective iNOS inhibitor -
生理活性の詳細
Selective iNOS inhibitor, 5000-fold selective over eNOS (Kd values are ≤7 nM, 2 μM and 50 μM at human iNOS, nNOS and eNOS, respectively).
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CAS 番号
214358-33-5 -
構造式
製品の特性
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体系名
N-[3-(Aminomethyl)benzyl]acetamidine dihydrochloride -
分子量
250.17 -
分子式
C10H15N3.2HCl -
PubChem 登録番号
2733515 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Cl.Cl.CC(=N)NCc1cccc(c1)CN -
由来
Synthetic
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研究分野
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Nitric oxide & oxidative stress
- NOS
- Inhibitors
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Obesity
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
関連製品
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Related Products
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (5)
ab120165 は 5 報の論文で使用されています。
- Simpson DS et al. Interferon-? primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Immunity 55:423-441.e9 (2022). PubMed: 35139355
- Xian Bo S et al. An Inducible Nitric Oxide Synthase Dimerization Inhibitor Prevents the Progression of Osteoarthritis. Front Pharmacol 13:861183 (2022). PubMed: 35910349
- Liu L et al. Inhibition of inducible nitric oxide synthase improved erectile dysfunction in rats with type 1 diabetes. Andrologia 53:e14138 (2021). PubMed: 34137064
- Jiang L et al. Lysosomal nitric oxide determines transition from autophagy to ferroptosis after exposure to plasma-activated Ringer's lactate. Redox Biol 43:101989 (2021). PubMed: 33940548
- Tanemoto R et al. The constituents of licorice (Glycyrrhiza uralensis) differentially suppress nitric oxide production in interleukin-1ß-treated hepatocytes. Biochem Biophys Rep 2:153-159 (2015). PubMed: 29124157