(-)-Nicotine ditartrate, nicotinic acetylcholine receptor agonist (ab120562)
Key features and details
- Potent nAChR agonist
- CAS Number: 65-31-6
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
(-)-Nicotine ditartrate, nicotinic acetylcholine receptor agonist -
製品の詳細
Potent nAChR agonist -
生理活性の詳細
Potent nicotinic acetylcholine receptor (nAChR) agonist. Stimulates autonomic ganglia and skeletal muscle neuromuscular junctions. Reduces beta-amyloidosis in a mouse model of Alzheimer's disease. (Ki values are 16.1 (α4β2), 2110 (α7), 520 (α3β4), 270 (α6/α4β4) and 2090 nM (α1β1γδ)).
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CAS 番号
65-31-6 -
構造式
製品の特性
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体系名
(S)-(-)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-ditartrate salt -
分子量
462.41 -
分子式
C10H14N2.2C4H6O6 -
保存方法
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Synthetic
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研究分野
画像
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (1)
ab120562 は 1 報の論文で使用されています。
- Notaras M et al. Neurodevelopmental signatures of narcotic and neuropsychiatric risk factors in 3D human-derived forebrain organoids. Mol Psychiatry 26:7760-7783 (2021). PubMed: 34158620