製品の概要

  • 製品名

    (-)-Cannabidiol, Natural cannabinoid
  • 製品の詳細

    Common constituent of Cannabis
  • 別名

    • CBD
  • 生理活性の詳細

    Common constituent of Cannabis with much lower affinity at CB1 and CB2 receptors (Ki values are 4350 and 2860 nM, respectively) than Delta-9 THC. Elicits anticonvulsant, anticancer, anti-inflammatory and neuroprotective effects. Protects retinal neurons in diabetic models.
  • 精製度

    > 98%
  • CAS 番号

    13956-29-1
  • 構造式

    Chemical Structure

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab120448 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Functional Studies Use at an assay dependent concentration.

画像

  • ab109225 staining Nox4 in HeLa cells treated with (-)-cannabidiol (ab120448), by ICC/IF. Increase in Nox4 expression correlates with increased concentration of (-)-cannabidiol, as described in literature.
    The cells were incubated at 37°C for 6h in media containing different concentrations of ab120847 ((-)-cannabidiol) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab109225 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

参考文献

This product has been referenced in:

  • El-Remessy AB  et al. Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes. Mol Vis 16:1487-95 (2010). Read more (PubMed: 20806080) »
  • Pertwee RG The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. Br J Pharmacol 153:199-215 (2008). Read more (PubMed: 17828291) »
  • McAllister SD  et al. Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells. Mol Cancer Ther 6:2921-7 (2007). Read more (PubMed: 18025276) »

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