(-)-Bicuculline methiodide, GABAA antagonist (ab120108)
Key features and details
- GABAA antagonist
- CAS Number: 40709-69-1
- Soluble in water to 10 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
(-)-Bicuculline methiodide, GABAA antagonist -
製品の詳細
GABAA antagonist -
CAS 番号
40709-69-1 -
構造式
製品の特性
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体系名
[S-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide -
分子量
509.29 -
分子式
C21H20INO6 -
PubChem 登録番号
185826 -
保存方法
Store at +4°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 10 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
To be used on the same day after reconstitution.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
[I-].C[N+]5(C)CCc1cc6OCOc6cc1[C@@H]5[C@H]4OC(=O)c3c4ccc2OCOc23 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (33)
ab120108 は 33 報の論文で使用されています。
- Eichler A et al. Microglial Cytokines Mediate Plasticity Induced by 10 Hz Repetitive Magnetic Stimulation. J Neurosci 43:3042-3060 (2023). PubMed: 36977586
- Lenz M et al. Denervated mouse CA1 pyramidal neurons express homeostatic synaptic plasticity following entorhinal cortex lesion. Front Mol Neurosci 16:1148219 (2023). PubMed: 37122623
- Zheng R et al. KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization. Elife 11:N/A (2022). PubMed: 35138249
- Yong XLH et al. Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIa phosphorylation of the GluN2A subunit. Cell Rep 36:109338 (2021). PubMed: 34233182
- Conde-Dusman MJ et al. Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly. Elife 10:N/A (2021). PubMed: 34787081