製品の概要

  • 製品名Anti-ZNRF2 antibody
    ZNRF2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to ZNRF2
  • アプリケーション適用あり: WB, IPmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Horse, Chicken, Guinea pig, Cow, Turkey, Pig, Chimpanzee, Zebrafish, Rhesus monkey, Tilapia, Orangutan, Medaka fish
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 192-242 of Human ZNRF2 (NP_667339.1)

  • ポジティブ・コントロール
    • HeLa or 293T cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab86778 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/5000. Predicted molecular weight: 24 kDa.
IP Use at 10 µg/mg of lysate.

ターゲット情報

  • 機能May play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
  • 組織特異性Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.
  • パスウェイProtein modification; protein ubiquitination.
  • 配列類似性Contains 1 RING-type zinc finger.
  • ドメインThe RING-type zinc finger domain is required for E3 ligase activity.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Endosome membrane. Lysosome membrane. Cell junction > synapse > presynaptic cell membrane. Present in presynaptic plasma membranes in neurons.
  • Information by UniProt
  • 参照データベース
  • 別名
    • E3 ubiquitin-protein ligase ZNRF2 antibody
    • Protein Ells2 antibody
    • RING finger protein 202 antibody
    • RNF202 antibody
    • Zinc/RING finger protein 2 antibody
    • Znrf2 antibody
    • ZNRF2_HUMAN antibody
    see all

Anti-ZNRF2 antibody 画像

  • All lanes : Anti-ZNRF2 antibody (ab86778) at 0.4 µg/ml

    Lane 1 : HeLa cell lysate at 50 µg
    Lane 2 : HeLa cell lysate at 15 µg
    Lane 3 : HeLa cell lysate at 5 µg
    Lane 4 : 293T cell lysate at 50 µg

    Developed using the ECL technique

    Predicted band size : 24 kDa


    Exposure time : 3 minutes
  • HeLa whole cell lysate (1 mg) was immunoprecipitated with 10 µg ab86778 (lane 1) or control IgG antibody (lane 2). 20% of the immunoprecipitate was subjected to Western blotting and detected with ab86778 at 1 µg/ml. Bands were detected by chemiluminescence with an exposure time of 30 seconds.

Anti-ZNRF2 antibody (ab86778) 使用論文

ab86778 has not yet been referenced specifically in any publications.

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