製品の概要

  • 製品名Anti-ZNF521 antibody
    ZNF521 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to ZNF521
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    C-Terminus of human ZNF521

  • ポジティブ・コントロール
    • Human Kidney and Small Intestine tissues.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab113835 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 5 µg/ml.

ターゲット情報

  • 機能Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes.
  • 組織特異性Predominantly expressed in hematopoietic cells. Present in organs and tissues that contain stem and progenitor cells, myeloid and/or lymphoid: placenta, spleen, lymph nodes, thymus, bone marrow and fetal liver. Within the hematopoietic system, it is abundant in CD34(+) cells but undetectable in mature peripheral blood leukocytes, and its levels rapidly decrease during the differentiation of CD34(+) cells in response to hemopoietins.
  • 関連疾患Note=A chromosomal aberration involving ZNF521 is found in acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with PAX5. The translocation generates the PAX5-ZNF521 oncogene consisting of the N-terminus part of PAX5 and the C-terminus part of ZNF521.
  • 配列類似性Belongs to the krueppel C2H2-type zinc-finger protein family.
    Contains 30 C2H2-type zinc fingers.
  • ドメインUses different DNA- and protein-binding zinc fingers to regulate the distinct BMP-Smad and hematopoietic system.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • B930086A16Rik antibody
    • DKFZp564D0764 antibody
    • Early hematopoietic zinc finger antibody
    • Early hematopoietic zinc finger protein antibody
    • EHZF antibody
    • Evi3 antibody
    • LYST-interacting protein 3 antibody
    • MGC142182 antibody
    • MGC142208 antibody
    • Zfp521 antibody
    • Zinc finger protein 521 antibody
    • ZN521_HUMAN antibody
    • Znf521 antibody
    see all

Anti-ZNF521 antibody 画像

  • ab113835, at 5µg/ml, staining ZNF521 in formalin-fixed, paraffin-embedded Human Small Intestine tissue by Immunohistochemistry.
  • ab113835, at 5µg/ml, staining ZNF521 in formalin-fixed, paraffin-embedded Human Kidney tissue by Immunohistochemistry.

Anti-ZNF521 antibody (ab113835) 使用論文

ab113835 has not yet been referenced specifically in any publications.

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Expiration date: 25-11-2012

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