ZM 241385, A2A antagonist (ab120218)
Key features and details
- Potent, selective A2A antagonist
- CAS Number: 139180-30-6
- Soluble in DMSO to 100 mM and in ethanol to 5 mM (with warming)
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
ZM 241385, A2A antagonist -
製品の詳細
Potent, selective A2A antagonist -
生理活性の詳細
Potent A2 adenosine receptor antagonist, with approx 50-fold selectivity for A2A receptors. (Ki values are <1 nM, 50 nM, 255 nM and >10 μM at human cloned A2A, A2B, A1 and A3 receptors, respectively). Orally active in vivo.
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CAS 番号
139180-30-6 -
構造式
製品の特性
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体系名
4-(2-[7-Amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol -
分子量
337.34 -
分子式
C16H15N7O2 -
PubChem 登録番号
176407 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM and in ethanol to 5 mM (with warming) -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Oc1ccc(cc1)CCNc2nc(N)n3nc(nc3n2)c4ccco4 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (1)
ab120218 は 1 報の論文で使用されています。
- Basu M et al. Increased host ATP efflux and its conversion to extracellular adenosine is crucial for establishing Leishmania infection. J Cell Sci 133:N/A (2020). PubMed: 32079656