製品の概要

  • 製品名
    Ziprasidone (CP 88059)
  • 製品の詳細
    Atypical antipsychotic. 5-HT2A / D2 antagonist.
  • 別名
    • CP 88059
  • 生理活性の詳細
    Atypical antipsychotic that exhibits combined serotonin and dopamine receptor antagonist activity. Displays high affinity at 5-HT2A receptors with an in vitro 5-HT2A /D2 affinity ratio greater than any other clinically available atypical antipsychotics (pKi values are 9.38 and 8.32, respectively).
  • 精製度
    > 99%

製品の特性

画像

  • ab13524 staining LAMP2 in HepG2 cells treated with ziprasidone (ab120394), by ICC/IF. Increase in LAMP2 expression correlates with increased concentration of ziprasidone, as described in literature.
    The cells were incubated at 37°C for 24 hour in media containing different concentrations of ab120394 (ziprasidone) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab13524 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rat polyclonal antibody (ab98386) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

参考文献

This product has been referenced in:
  • Schmidt AW  et al. Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile. Eur J Pharmacol 425:197-201 (2001). Read more (PubMed: 11513838) »
  • Sprouse JS  et al. Comparison of the novel antipsychotic ziprasidone with clozapine and olanzapine: inhibition of dorsal raphe cell firing and the role of 5-HT1A receptor activation. Neuropsychopharmacology 21:622-31 (1999). Read more (PubMed: 10516958) »
  • Seeger TF  et al. Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity. J Pharmacol Exp Ther 275:101-13 (1995). Read more (PubMed: 7562537) »

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