製品の概要

  • 製品名ZIP
  • 製品の詳細
    Novel, cell-permeable protein kinase Mζ (PKMζ) inhibitor
  • 別名
    • z-Pseudosubstrate inhibitory peptide
  • 生理活性の詳細Novel, cell-permeable PKMζ inhibitor, a constitutively active, atypical PKC isozyme. Efficacious in in vitro and in vivo models of synaptic plasticity (IC50 = 1 - 2.5 μM).
  • 精製度> 96%

製品の特性

  • 分子量1928.40
  • 構造式Chemical Structure
  • 分子式C90H154N30O17
  • CAS 番号863987-12-6
  • 配列SIYRRGARRWRKL (Modifications: N-terminal myristyl)
  • 保存方法Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性Soluble in water
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • 由来

    Synthetic

  • 研究分野

    ZIP (ab120993) 使用論文

    This product has been referenced in:
    • Wu-Zhang AX  et al. Cellular pharmacology of protein kinase M? (PKM?) contrasts with its in vitro profile: implications for PKM? as a mediator of memory. J Biol Chem 287:12879-85 (2012). Read more (PubMed: 22378786) »
    • Cai D  et al. Protein kinase M maintains long-term sensitization and long-term facilitation in aplysia. J Neurosci 31:6421-31 (2011). Read more (PubMed: 21525283) »
    • Serrano P  et al. Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term potentiation. J Neurosci 25:1979-84 (2005). Read more (PubMed: 15728837) »

    See 0 Publications for this product

    Product Wall



    Generally, we check all vials after freeze drying to satisfy ourselves that there is product in the vial, but it isn’t always possible to see a nice fluffy plug of material in the bottom of the vial; sometimes the result is a thin film ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"