製品の概要

  • 製品名Anti-Zic2 antibody
    Zic2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to Zic2
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant tagged fragment (Human)

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab61278 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報ELISA: Use at an assay dependent dilution.
    WB: Use at a concentration of 1 - 5 µg/ml. Predicted molecular weight: 55 kDa.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.
    • 関連疾患Defects in ZIC2 are a cause of holoprosencephaly type 5 (HPE5) [MIM:609637]. A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. Although severe facial anomalies are common in HPE, patients with ZINC2 mutations have relatively normal faces.
    • 配列類似性Belongs to the GLI C2H2-type zinc-finger protein family.
      Contains 5 C2H2-type zinc fingers.
    • ドメインThe C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation.
    • 翻訳後修飾Phosphorylated.
      Ubiquitinated by RNF180, leading to its degradation.
    • 細胞内局在Nucleus. Cytoplasm. Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • HPE 5 antibody
      • HPE5 antibody
      • Odd paired homolog Drosophila antibody
      • Zic 2 antibody
      • Zic family member 2 (odd paired Drosophila homolog) antibody
      • Zic family member 2 antibody
      • ZIC2 antibody
      • ZIC2_HUMAN antibody
      • Zinc finger protein of the cerebellum 2 antibody
      • Zinc finger protein ZIC 2 antibody
      • Zinc finger protein Zic2 antibody
      see all

    Anti-Zic2 antibody 画像



    • Predicted band size : 55 kDa

    Anti-Zic2 antibody (ab61278) 使用論文

    ab61278 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab61278.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"