製品の概要

  • 製品名Anti-Zic1 antibody
    Zic1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Zic1
  • 特異性ab72694 detects endogenous levels of total Zic1 protein.
  • アプリケーション適用あり: ICC/IF, WB, ELISA, IHC-P, IHC-Frmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide derived from an internal sequence of human Zic1

  • ポジティブ・コントロール
    • Jurkat and COLO cell extracts. Paraffin embedded human brain tissue.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab72694 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use at an assay dependent concentration. PubMed: 20713527
WB 1/500 - 1/1000. Detects a band of approximately 48 kDa (predicted molecular weight: 48 kDa).
ELISA 1/20000.
IHC-P 1/50 - 1/100.
IHC-Fr Use at an assay dependent concentration. PubMed: 23603813

ターゲット情報

  • 機能Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.
  • 組織特異性CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined.
  • 配列類似性Belongs to the GLI C2H2-type zinc-finger protein family.
    Contains 5 C2H2-type zinc fingers.
  • ドメインThe C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation.
  • 細胞内局在Nucleus. Cytoplasm. Localizes in the cytoplasm in presence of MDFIC overexpression.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Odd paired homolog Drosophila antibody
    • Zic 1 antibody
    • ZIC antibody
    • Zic family member 1 (odd-paired Drosophila homolog) antibody
    • Zic family member 1 antibody
    • Zic protein member 1 antibody
    • zic1 antibody
    • ZIC1_HUMAN antibody
    • Zinc finger protein 201 antibody
    • Zinc finger protein of the cerebellum 1 antibody
    • Zinc finger protein ZIC 1 antibody
    • Zinc finger protein ZIC1 antibody
    • ZNF 201 antibody
    • ZNF201 antibody
    see all

Anti-Zic1 antibody 画像

  • All lanes : Anti-Zic1 antibody (ab72694) at 1/500 dilution

    Lane 1 : Jurkat cell extract
    Lane 2 : COLO cell extract
    Lane 3 : Jurkat cell extract with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 48 kDa
    Observed band size : 48 kDa
  • ab72694 at 1/50 dilution staining Zic1 in human brain by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.

Anti-Zic1 antibody (ab72694) 使用論文

This product has been referenced in:

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"