製品の概要

  • 製品名
    ZD7288
  • 製品の詳細
    Sino-atrial node function modulator
  • 別名
    • ICI D7288
  • 生理活性の詳細
    Sino-atrial node function modulator; blocks the hyperpolarisation activated inward current If. Also inhibits Ih in central neurons and inhibits synaptic transmission.
  • 精製度
    > 98%

製品の特性

参考文献

This product has been referenced in:
  • Inaba Y  et al. The H current blocker ZD7288 decreases epileptiform hyperexcitability in the rat neocortex by depressing synaptic transmission. Neuropharmacology 51:681-91 (2006). Read more (PubMed: 16806308) »
  • Harris NC & Constanti A Mechanism of block by ZD 7288 of the hyperpolarization-activated inward rectifying current in guinea pig substantia nigra neurons in vitro. J Neurophysiol 74:2366-78 (1995). Read more (PubMed: 8747199) »
  • BoSmith RE  et al. Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells. Br J Pharmacol 110:343-9 (1993). Read more (PubMed: 7693281) »

See all 14 Publications for this product

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