製品の概要
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製品名Anti-ZAK antibody
ZAK 一次抗体 製品一覧 -
製品の詳細Rabbit polyclonal to ZAK
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由来種Rabbit
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アプリケーション適用あり: WB, IHC-Pmore details
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種交差性交差種: Human
交差が予測される動物種: Mouse, Rat
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免疫原
Recombinant fragment, corresponding to amino acids 36-264 of Human ZAK (BC001401).
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ポジティブ･コントロール
- HeLa, Human Fetal Lymph
法規制情報
製品の特性
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製品の状態Lyophilised:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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バッファーPreservative: 0.02% Sodium Azide
Constituents: PBS, pH 7.2 -
Concentration information loading... -
精製度Protein A purified
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
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Positive Controls
アプリケーション
Our Abpromise guarantee covers the use of ab99933 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | 1/500 - 1/1000. Predicted molecular weight: 91 kDa. | |
| IHC-P | 1/100 - 1/500. |
ターゲット情報
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機能Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'.
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組織特異性Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.
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配列類似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Contains 1 protein kinase domain.
Contains 1 SAM (sterile alpha motif) domain. -
細胞内局在Cytoplasm. Nucleus. Translocates to the nucleus upon ultraviolet B irradiation.
- Information by UniProt
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参照データベース
- Entrez Gene: 51776 Human
- Entrez Gene: 65964 Mouse
- Entrez Gene: 311743 Rat
- Omim: 609479 Human
- SwissProt: Q9NYL2 Human
- SwissProt: Q9ESL4 Mouse
- Unigene: 444451 Human
- Unigene: 304143 Mouse
see all -
別名
- AZK antibody
- Cervical cancer suppressor gene 4 protein antibody
- HCCS 4 antibody
see all
画像
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Western blot - Anti-ZAK antibody (ab99933)Anti-ZAK antibody (ab99933) at 1/500 dilution + HeLa Cell Lysate
Predicted band size: 91 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZAK antibody (ab99933)Staining of Human ZAK in a Formalin/PFA-fixed paraffin-embedded section of Human Fetal Lymph using ab99933 at a dilution of 1/100.
参考文献
ab99933 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"