Anti-ZAK 抗体 (ab99933)

製品の概要

• 製品名
  Anti-ZAK antibody
  ZAK 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to ZAK
• アプリケーション
  適用あり: WB, IHC-Pmore details
• 種交差性
  交差種: Human
  交差が予測される動物種: Mouse, Rat
• 免疫原

  Recombinant fragment, corresponding to amino acids 36-264 of Human ZAK (BC001401).

• ポジティブ･コントロール
  • HeLa, Human Fetal Lymph

製品の特性

• 製品の状態
  Lyophilised:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファー
  Preservative: 0.02% Sodium Azide
  Constituents: PBS, pH 7.2
• Concentration information loading...
• 精製度
  Protein A purified
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Kinases
  • MAPK Pathway

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • HeLa whole cell lysate (ab29545)

アプリケーション

ターゲット情報

• 機能
  Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'.
• 組織特異性
  Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.
• 配列類似性
  Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
  Contains 1 protein kinase domain.
  Contains 1 SAM (sterile alpha motif) domain.
• 細胞内局在
  Cytoplasm. Nucleus. Translocates to the nucleus upon ultraviolet B irradiation.

• Target information above from: UniProt accession Q9NYL2 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 51776 Human
  • Entrez Gene: 65964 Mouse
  • Entrez Gene: 311743 Rat
  • Omim: 609479 Human
  • SwissProt: Q9NYL2 Human
  • SwissProt: Q9ESL4 Mouse
  • Unigene: 444451 Human
  • Unigene: 304143 Mouse

  • Unigene: 314618 Mouse
  • Unigene: 168007 Rat

  see all
• 別名
  • AZK antibody
  • Cervical cancer suppressor gene 4 protein antibody
  • HCCS 4 antibody

  • HCCS-4 antibody
  • HCCS4 antibody
  • Human cervical cancer suppressor gene 4 protein antibody
  • Leucine zipper and sterile alpha motif containing kinase antibody
  • Leucine zipper- and sterile alpha motif-containing kinase antibody
  • Mitogen activated protein kinase kinase kinase MLT antibody
  • Mitogen-activated protein kinase kinase kinase MLT antibody
  • Mixed lineage kinase 7 antibody
  • Mixed lineage kinase related kinase antibody
  • Mixed lineage kinase related kinase MRK beta antibody
  • Mixed lineage kinase with a leucine zipper and a sterile alpha motif antibody
  • Mixed lineage kinase-related kinase antibody
  • MLK 7 antibody
  • MLK like mitogen activated protein triple kinase antibody
  • MLK related kinase antibody
  • MLK-like mitogen-activated protein triple kinase antibody
  • MLK-related kinase antibody
  • MLK7 antibody
  • Mlklak antibody
  • MLT antibody
  • MLTK_HUMAN antibody
  • MRK antibody
  • Sterile alpha motif and leucine zipper containing kinase AZK antibody
  • Sterile alpha motif- and leucine zipper-containing kinase AZK antibody
  • Zak antibody

  see all

プロトコール

• Western blot protocols
• Immunohistochemistry protocols