YEKL motif (clathrin AP-2 binding motif) (ab120380)

製品の概要

  • 製品名
    YEKL motif (clathrin AP-2 binding motif)
  • 製品の詳細
    Competes with AP-2 binding to NR2B
  • 生理活性の詳細
    Peptide that competes with clathrin adaptor protein (AP-2) binding to NR2B, thought to be involved in synaptic regulation and internalisation of NMDA receptors. Contains the distal tyrosine motif of NR2B (YEKL) which acts as an internalisation motif. Induces a rapid increase in NMDA-mediated miniature post-synaptic currents in transfected cerebellar granule cells.

製品の特性

参考文献

This product has been referenced in:
  • Prybylowski K  et al. The synaptic localization of NR2B-containing NMDA receptors is controlled by interactions with PDZ proteins and AP-2. Neuron 47:845-57 (2005). Read more (PubMed: 16157279) »

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