製品の概要

  • 製品名
    YC-1
  • 製品の詳細
    Reversible soluble guanylyl cyclase activator
  • 生理活性の詳細
    Reversible soluble guanylyl cyclase activator (EC50 = 18.6 μM). NO-independent. Induces a concentration dependent increase in cGMP in vitro. Reduces blood-brain barrier permeability through HIF-1 inhibiton in vivo.
  • 精製度
    > 99%

製品の特性

  • 体系名
    5-[1-(Phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol
  • 分子量
    304.35
  • 構造式
    Chemical Structure
  • 分子式
    C19H16N2O2
  • CAS 番号
    170632-47-0
  • PubChem 登録番号
    5712
  • 保存方法
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性
    Soluble in ethanol to 50 mM and in DMSO to 50 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記
    OCC1=CC=C(C2=NN(CC3=CC=CC=C3)C4=C2C=CC=C4)O1
  • 由来

    Synthetic

  • 研究分野

参考文献

This product has been referenced in:
  • Yan J  et al. Differential effects of HIF-1 inhibition by YC-1 on the overall outcome and blood-brain barrier damage in a rat model of ischemic stroke. PLoS One 6:e27798 (2011). Read more (PubMed: 22110762) »
  • Pal B & Kitagawa T Binding of YC-1/BAY 41-2272 to soluble guanylate cyclase: A new perspective to the mechanism of activation. Biochem Biophys Res Commun 397:375-9 (2010). Read more (PubMed: 20513359) »
  • Mülsch A  et al. Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators. Br J Pharmacol 120:681-9 (1997). Read more (PubMed: 9051308) »

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