製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to XRCC3
  • アプリケーション
    適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant protein fragment contain a sequence corresponding to a region within amino acids 202 and 346 of XRCC3

  • ポジティブ・コントロール
    • HepG2 and HeLa cell lines

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab97390 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 38 kDa.
ICC/IF 1/100 - 1/200.

ターゲット情報

  • 機能
    Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.
  • 配列類似性
    Belongs to the RecA family. RAD51 subfamily.
  • 翻訳後修飾
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在
    Nucleus. Cytoplasm. Cytoplasm > perinuclear region. Mitochondrion. Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CMM6 antibody
    • DNA repair protein XRCC3 antibody
    • RAD51 like antibody
    • X ray repair complementing defective repair in Chinese hamster antibody
    • X ray repair complementing defective repair in Chinese hamster cells 3 antibody
    • X ray repair cross complementing protein 3 antibody
    • X-ray repair cross-complementing protein 3 antibody
    • XRCC 3 antibody
    • XRCC3 antibody
    • XRCC3_HUMAN antibody
    see all

画像

  • Anti-XRCC3 antibody (ab97390) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 38 kDa
  • ab97390, at a 1/200 dilution, staining XRCC3 in paraformaldehyde fixed HeLa by Immunofluorescence.
    Lower image was merged with DNA probe.

参考文献

This product has been referenced in:
  • Prensner JR  et al. PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer. Cancer Res 74:1651-60 (2014). WB . Read more (PubMed: 24473064) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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