製品の概要
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製品名Anti-XRCC3 antibody
XRCC3 一次抗体 製品一覧 -
製品の詳細Rabbit polyclonal to XRCC3
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由来種Rabbit
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アプリケーション適用あり: WB, ICC/IFmore details
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種交差性交差種: Human
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免疫原
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 202 and 346 of XRCC3
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ポジティブ･コントロール
- HepG2 and HeLa cell lines
法規制情報
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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バッファーPreservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0 -
Concentration information loading... -
精製度Immunogen affinity purified
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
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Positive Controls
アプリケーション
Our Abpromise guarantee covers the use of ab97390 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | 1/500 - 1/3000. Predicted molecular weight: 38 kDa. | |
| ICC/IF | 1/100 - 1/200. |
ターゲット情報
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機能Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.
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配列類似性Belongs to the RecA family. RAD51 subfamily.
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翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
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細胞内局在Nucleus. Cytoplasm. Cytoplasm > perinuclear region. Mitochondrion. Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair.
- Information by UniProt
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参照データベース
- Entrez Gene: 7517 Human
- Omim: 600675 Human
- SwissProt: O43542 Human
- Unigene: 592325 Human
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別名
- CMM6 antibody
- DNA repair protein XRCC3 antibody
- RAD51 like antibody
see all
画像
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Western blot - Anti-XRCC3 antibody (ab97390)Anti-XRCC3 antibody (ab97390) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg
Predicted band size: 38 kDa -
Immunocytochemistry/ Immunofluorescence - Anti-XRCC3 antibody (ab97390)ab97390, at a 1/200 dilution, staining XRCC3 in paraformaldehyde fixed HeLa by Immunofluorescence.
Lower image was merged with DNA probe.
参考文献
This product has been referenced in:
- Prensner JR et al. PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer. Cancer Res 74:1651-60 (2014). WB . Read more (PubMed: 24473064) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"