The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent dilution. Predicted molecular weight: 34 kDa.
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
Belongs to the RecA family. RAD51 subfamily.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Xu K et al. XRCC2 rs3218536 polymorphism decreases the sensitivity of colorectal cancer cells to poly(ADP-ribose) polymerase 1 inhibitor. Oncol Lett8:1222-1228 (2014).
Read more (PubMed: 25120693) »
Gildemeister OS et al. Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C. J Biol Chem284:31945-52 (2009).
Read more (PubMed: 19783859) »