Anti-XRCC1 (phospho S518 + T519 + T523) 抗体 (ab84417)

製品の概要

  • 製品名Anti-XRCC1 (phospho S518 + T519 + T523) antibody
    XRCC1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to XRCC1 (phospho S518 + T519 + T523)
  • アプリケーション適用あり: IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Chimpanzee, Gorilla
  • 免疫原

    Synthetic peptide to a region surrounding residues Ser 518, Thr 519 and Thr 523 of Human XRCC1, Swiss Prot P18887.

  • ポジティブ・コントロール
    • Human Controls: B-cell lymphoma, breast carcinoma, colon carcinoma, laryngeal squamous cell carcinoma, linitis plastica stomach cancer, metastatic lymph node, ovarian carcinoma, pancreatic islet cell tumor, prostate carcinoma, skin basal cell carcinoma, small cell lung cancer, stomach adenocarcinoma, testicular seminoma.
      Mouse Controls: colon carcinoma CT26, squamous cell carcinoma.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab84417 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
ICC/IF
  • 追加情報ICC/IF: 1/100.
    IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
    • 配列類似性Contains 2 BRCT domains.
    • 翻訳後修飾Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.
      Sumoylated.
    • 細胞内局在Nucleus. Accumulates at sites of DNA damage.
    • Information by UniProt
    • 参照データベース
    • 別名
      • DNA repair protein XRCC1 antibody
      • RCC antibody
      • X ray repair complementing defective repair in chinese hamster antibody
      • X ray Repair Complementing Defective Repair in Chinese Hamster Cells antibody
      • X ray repair complementing defective repair in chinese hamster cells 1 antibody
      • X ray repair cross complementing 1 antibody
      • X ray repair cross complementing protein 1 antibody
      • X ray repair, complementing defective, repair in Chinese hamster antibody
      • X-ray repair cross-complementing protein 1 antibody
      • XRCC 1 antibody
      • Xrcc1 antibody
      • XRCC1_HUMAN antibody
      see all

    Anti-XRCC1 (phospho S518 + T519 + T523) antibody 画像

    • Detection of Human XRCC1 (phospho S518 + T519 + T523) by Immunohistochemistry.
      Samples: FFPE serial sections of Human breast adenocarcinoma. Mock phosphatase treated section (left) or calf intestinal phosphatase-treated section (right) immunostained for XRCC1 (phospho S518 + T519 + T523).
      Antibody: ab84417 used at a dilution of 1/250.
      Detection: DAB staining.
    • Detection of Mouse XRCC1 (phospho S518 + T519 + T523) by Immunohistochemistry.
      Samples: FFPE serial sections of Mouse squamous cell carcinoma. Mock phosphatase treated section (left) or calf intestinal phosphatase-treated section (right) immunostained for XRCC1 (phospho S518 + T519 + T523).
      Antibody: ab84417 used at a dilution of 1/250. Detection: DAB staining.
    • Detection of Human XRCC1 (phospho S518 + T519 + T523) by Immunofluorescence.
      Sample: FFPE section of Human breast carcinoma.
      Antibody: ab84417 used at a dilution of 1/100.
      Detection: Red-fluorescent Alexa Fluor 555 goat anti-rabbit IgG used at a dilution of 1/500.

    Anti-XRCC1 (phospho S518 + T519 + T523) antibody (ab84417) 使用論文

    ab84417 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"