製品の概要

  • 製品名Anti-XPNPEP3 antibody
    XPNPEP3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to XPNPEP3
  • アプリケーション適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 12 and 482 of XPNPEP3 (NP_071381).

  • ポジティブ・コントロール
    • WB: A431 whole cell lysate; 293T, H1299, HepG2, MOLT4 and Raji cell lysates ICC/IF: A549 cells

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab95982 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 57 kDa.
ICC/IF 1/100 - 1/200.

ターゲット情報

  • 組織特異性Isoform 1 and isoform 2 are widely expressed, with isoform 1 being more abundant.
  • 関連疾患Defects in XPNPEP3 are the cause of nephronophthisis-like nephropathy type 1 (NPHPL1) [MIM:613159]. A disorder with features of nephronophthisis, a cystic kidney disease leading to end-stage renal failure. Nephronophthisis is histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts. Typical clinical manifestation are chronic renal failure, anemia, polyuria, polydipsia, isosthenuria, and growth retardation. Associations with extrarenal symptoms are frequent. In NPHPL1 patients, extrarenal symptoms include hypertension, essential tremor, sensorineural hearing loss and gout. Severely affected individuals can manifest a mitochondrial disorder with isolated complex I deficiency activity in muscle, seizures, mental retardation and hypertrophic dilated cardiomyopathy.
  • 配列類似性Belongs to the peptidase M24B family.
  • 細胞内局在Mitochondrion.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Aminopeptidase P3 antibody
    • APP3 antibody
    • NPHPL1 antibody
    • OTTHUMP00000199806 antibody
    • Probable Xaa Pro aminopeptidase 3 antibody
    • Probable Xaa-Pro aminopeptidase 3 antibody
    • X Pro aminopeptidase 3 antibody
    • X prolyl aminopeptidase (aminopeptidase P) 3 antibody
    • X-Pro aminopeptidase 3 antibody
    • XPNPEP3 antibody
    • XPP3_HUMAN antibody
    see all

Anti-XPNPEP3 antibody 画像

  • Anti-XPNPEP3 antibody (ab95982) at 1/500 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 57 kDa
  • Immunofluorescence analysis of XPNPEP3 in paraformaldehyde fixed A549, using ab95982 at 1/200 dilution. Lower image merged with DNA probe.

Anti-XPNPEP3 antibody (ab95982) 使用論文

ab95982 has not yet been referenced specifically in any publications.

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