製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to XPF
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Chimpanzee, Rhesus monkey, Gorilla
  • 免疫原

    Synthetic peptide, corresponding to a region between residues 855 and 905 of human XPF (AAB07689.1)

  • ポジティブ・コントロール
    • Human Breast Carcinoma and Prostate Carcinoma tissues.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    Preservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    ab84540 was affinity purified using an epitope specific to XPF immobilized on solid support.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab84540 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報
    IHC-P: 1/100 - 1/500.
    Epitope exposure with citrate buffer will enhance staining and is recommended

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.
    • 関連疾患
      Defects in ERCC4 are the cause of xeroderma pigmentosum complementation group F (XP-F) [MIM:278760]; also known as xeroderma pigmentosum VI (XP6). XP-F is an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities.
      Defects in ERCC4 are a cause of XFE progeroid syndrome (XFEPS) [MIM:610965]. This syndrome is illustrated by one patient who presented with dwarfism, cachexia and microcephaly.
    • 配列類似性
      Belongs to the XPF family.
      Contains 1 ERCC4 domain.
    • 細胞内局在
      Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • DNA excision repair protein ERCC 4 antibody
      • DNA excision repair protein ERCC-4 antibody
      • DNA excision repair protein ERCC4 antibody
      • DNA repair endonuclease XPF antibody
      • DNA repair protein complementing XP F cells antibody
      • DNA repair protein complementing XP-F cells antibody
      • ERCC 11 antibody
      • ERCC 4 antibody
      • ERCC11 antibody
      • ERCC4 antibody
      • Excision repair complementing defective in Chinese hamster antibody
      • Excision repair cross complementing rodent repair deficiency complementation group 4 antibody
      • excision repair cross-complementation group 4 antibody
      • FANCQ antibody
      • RAD 1 antibody
      • RAD1 antibody
      • Xeroderma pigmentosum complementation group F antibody
      • Xeroderma pigmentosum group F complementing protein antibody
      • Xeroderma pigmentosum group F-complementing protein antibody
      • Xeroderma pigmentosum VI antibody
      • XP, group G antibody
      • XP6 antibody
      • XPF_HUMAN antibody
      see all

    画像

    • ab84540 at 1/500 dilution staining XPF in human prostate carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

    プロトコール

    参考文献

    ab84540 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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