製品の概要

  • 製品名Anti-XPA antibody
    XPA 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to XPA
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rhesus monkey, Gorilla, Elephant
  • 免疫原

    Synthetic peptide, corresponding to a region between residue 1 and 50 of human XPA (NP_000371.1).

  • ポジティブ・コントロール
    • Human controls: Breast Carcinoma, Colon Carcinoma, Ovarian Carcinoma, Prostate Carcinoma, Stomach Adenocarcinoma, Testicular Seminoma Mouse controls: Teratoma

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab84780 was affinity purified using an epitope specific to XPA immobilized on solid support.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab84780 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
    • 組織特異性Expressed in various cell lines and in skin fibroblasts.
    • 関連疾患Defects in XPA are a cause of xeroderma pigmentosum complementation group A (XP-A) [MIM:278700]; also known as xeroderma pigmentosum type 1 (XP1). XP-A is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Group A patients show the most severe skin symptoms and progressive neurological disorders.
    • 配列類似性Belongs to the XPA family.
    • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
      Ubiquitinated by HERC2 leading to degradation by the proteasome.
    • 細胞内局在Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • DNA repair protein complementing XP A cells antibody
      • DNA repair protein complementing XP-A cells antibody
      • DNA repair protein complementing XPA cells antibody
      • Excision repair controlling antibody
      • Xeroderma pigmentosum 1 antibody
      • Xeroderma pigmentosum complementation group A antibody
      • Xeroderma pigmentosum group A complementing protein antibody
      • Xeroderma pigmentosum group A-complementing protein antibody
      • XP 1 antibody
      • XP1 antibody
      • xpa antibody
      • XPA_HUMAN antibody
      • Xpac antibody
      see all

    Anti-XPA antibody 画像

    • ab84780, at a 1/500 dilution, staining XPA in formalin fixed, paraffin embedded human ovarian tumor by Immunohistochemistry using DAB staining.
    • ab84780, at a 1/500 dilution, staining XPA in formalin fixed, paraffin embedded human colon carcinoma by Immunohistochemistry using DAB staining.
    • ab84780, at a 1/100 dilution, staining XPA in formalin fixed, paraffin embedded mouse teratoma by Immunohistochemistry using DAB staining.

    Anti-XPA antibody (ab84780) 使用論文

    ab84780 has not yet been referenced specifically in any publications.

    Product Wall

    Abcam guarantees this product to work in the species/application used in this Abreview.
    Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample Mouse Tissue sections (Adult skin)
    Specification Adult skin
    Fixative Paraformaldehyde
    Antigen retrieval step Heat mediated - Buffer/Enzyme Used: Ciitric buffer, pH 6
    Permeabilization No
    Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 20°C
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    投稿 Mar 24 2010

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"