製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to xCT
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Rat, Human
    交差が予測される動物種: Mouse, Dog, Pig, Orangutan
  • 免疫原

    Synthetic peptide:

    C-KGQTQNFKDAFSGRD

    , corresponding to internal sequence amino acids 215-229 of Human xCT

  • ポジティブ・コントロール
    • Human Spleen lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab60171 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.02 - 0.06 µg/ml. Detects a band of approximately 52 kDa (predicted molecular weight: 55 kDa).

ターゲット情報

  • 機能
    Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.
  • 配列類似性
    Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Amino acid transport system xc xCT antibody antibody
    • Amino acid transport system xc- antibody
    • Calcium channel blocker resistance protein CCBR1 antibody
    • Calcium channel blocker resistance protein CCBR1 antibody antibody
    • CCBR1 antibody
    • Cysteine/glutamate transporter antibody antibody
    • Cystine/glutamate transporter antibody
    • OTTHUMP00000164578 antibody
    • SLC7A11 antibody
    • Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 antibody
    • solute carrier family 7 antibody
    • Solute carrier family 7 member 11 antibody
    • Solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 antibody
    • SYSTEM Xc(-) TRANSPORTER-RELATED PROTEIN antibody
    • xCT antibody
    • XCT_HUMAN antibody
    see all

画像

プロトコール

参考文献

This product has been referenced in:
  • Ge C  et al. The down-regulation of SLC7A11 enhances ROS induced P-gp over-expression and drug resistance in MCF-7 breast cancer cells. Sci Rep 7:3791 (2017). WB ; Human . Read more (PubMed: 28630426) »
  • Ye JL  et al. EAAT3 promotes amino acid transport and proliferation of porcine intestinal epithelial cells. Oncotarget 7:38681-38692 (2016). WB . Read more (PubMed: 27231847) »

See all 4 Publications for this product

レビューと Q&A

Abcam guarantees this product to work in the species/application used in this Abreview.
Application
Western blot
Sample
Rat Tissue lysate - other (Spinal cord)
Loading amount
20 µg
Specification
Spinal cord
Treatment
4 hours after 300kdyne spinal cord injury
Gel Running Conditions
Reduced Denaturing (4-20% Tris-HCl gel)
Blocking step
Milk as blocking agent for 10 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 4°C
Username

Ms. Kelly Atkins

Verified customer

投稿 Oct 06 2010

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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