製品の概要

  • 製品名Anti-XBP1 antibody
    XBP1 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to XBP1
  • アプリケーション適用あり: WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Dog, Human
    交差が予測される動物種: Mouse, Chimpanzee, Gorilla
  • 免疫原

    Synthetic peptide:

    NHSWEDTFANELFPQ

    by a Cysteine residue linker, corresponding to C terminal amino acids 358-372 of Human XBP1 isoform 2

  • ポジティブ・コントロール
    • Human breast tissue; HeLa nuclear lysate

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab85546 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 40 kDa.
ELISA 1/4000.
IHC-P Use a concentration of 5 µg/ml.

ターゲット情報

  • 機能Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I.
  • 関連疾患Genetic variations in XBP1 could be associated with susceptibility to major affective disorder type 7 (MAFD7) [MIM:612371]. Major affective disorders represent a class of mental disorders characterized by a disturbance in mood as their predominant feature.
  • 配列類似性Belongs to the bZIP family.
    Contains 1 bZIP domain.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Tax responsive element binding protein 5 antibody
    • Tax-responsive element-binding protein 5 antibody
    • TREB5 antibody
    • X box binding protein 1 antibody
    • X box binding protein 2 antibody
    • X-box-binding protein 1 antibody
    • XBP 1 antibody
    • XBP-1 antibody
    • XBP1 antibody
    • XBP1_HUMAN antibody
    • XBP2 antibody
    see all

Anti-XBP1 antibody 画像

  • Immunohistochemical analysis of formalin-fixed paraffin-embedded human breast tissue using ab85546 at a dilution of 5µg/ml.
  • Anti-XBP1 antibody (ab85546) at 1 µg/ml + nuclear HeLa lysate in RIPA buffer at 35 µg

    Predicted band size : 40 kDa

Anti-XBP1 antibody (ab85546) 使用論文

ab85546 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample Mouse Tissue sections (Liver)
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: Citrat-buffer
Permeabilization No
Specification Liver
Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 1.5% · Temperature: 22°C
Fixative Paraformaldehyde
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Abcam user community

Verified customer

投稿 Dec 11 2015

Thank you very much for your call yesterday and for forwarding this dog sequence to me.

Looking at the alignment results, I do think it is quite possible for ab37152 to cross-react with your dog samples. I'm sending your information to Cedarl...

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Thank you for your call today and for your interest in our XBP1 antibodies. Please see below for information about your testing code, and let me know if you have any questions or if there is anything else that we can do for you.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"