Anti-XBP1 抗体 (ab85546)
Key features and details
- Goat polyclonal to XBP1
- Suitable for: ELISA, IHC-P
- Reacts with: Mouse, Dog, Human
- Isotype: IgG
製品の概要
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製品名
Anti-XBP1 antibody
XBP1 一次抗体 製品一覧 -
製品の詳細
Goat polyclonal to XBP1 -
由来種
Goat -
アプリケーション
適用あり: ELISA, IHC-Pmore details
適用なし: WB -
種交差性
交差種: Mouse, Dog, Human
交差が予測される動物種: Chimpanzee, Gorilla -
免疫原
Synthetic peptide:
NHSWEDTFANELFPQ
by a Cysteine residue linker, corresponding to C terminal amino acids 358-372 of Human XBP1 isoform 2 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab85546の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ELISA |
Use at an assay dependent concentration.
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IHC-P | (4) |
Use a concentration of 5 µg/ml.
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特記事項 |
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ELISA
Use at an assay dependent concentration. |
IHC-P
Use a concentration of 5 µg/ml. |
ターゲット情報
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機能
Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I. -
関連疾患
Genetic variations in XBP1 could be associated with susceptibility to major affective disorder type 7 (MAFD7) [MIM:612371]. Major affective disorders represent a class of mental disorders characterized by a disturbance in mood as their predominant feature. -
配列類似性
Belongs to the bZIP family.
Contains 1 bZIP domain. -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 7494 Human
- Entrez Gene: 22433 Mouse
- Omim: 194355 Human
- SwissProt: P17861 Human
- SwissProt: O35426 Mouse
- Unigene: 437638 Human
- Unigene: 469937 Mouse
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別名
- Tax responsive element binding protein 5 antibody
- Tax-responsive element-binding protein 5 antibody
- TREB5 antibody
see all
画像
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (4)
ab85546 は 4 報の論文で使用されています。
- Obert DP et al. ER stress preconditioning ameliorates liver damage after hemorrhagic shock and reperfusion. Exp Ther Med 21:248 (2021). PubMed: 33603856
- Pavlovic N et al. Inhibiting IRE1a-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma. Elife 9:N/A (2020). PubMed: 33103995
- Wolpert A et al. Hepatic topographical changes of endoplasmic reticulum stress and unfolded protein response signaling after hemorrhagic shock and reperfusion. J Surg Res 231:278-289 (2018). PubMed: 30278941
- Piret SE et al. A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress. Dis Model Mech 10:773-786 (2017). IHC-P ; Mouse . PubMed: 28325753