製品の概要

  • 製品名Anti-XBP1 antibody
    XBP1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to XBP1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Rat, Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 200 to the C-terminus of Human XBP1.

    (Peptide available as ab30769.)

  • ポジティブ・コントロール
    • This antibody gave a positive signal in the following lysates: Jurkat Whole Cell, A431 Whole Cell, Rat Testis Tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab28715 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1 µg/ml. Detects a band of approximately 35 kDa (predicted molecular weight: 33 kDa). We believe this band represents the protein product of the unprocessed XBP1 mRNA that is present in the absence of a stress response.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I.
    • 関連疾患Genetic variations in XBP1 could be associated with susceptibility to major affective disorder type 7 (MAFD7) [MIM:612371]. Major affective disorders represent a class of mental disorders characterized by a disturbance in mood as their predominant feature.
    • 配列類似性Belongs to the bZIP family.
      Contains 1 bZIP domain.
    • 細胞内局在Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Tax responsive element binding protein 5 antibody
      • Tax-responsive element-binding protein 5 antibody
      • TREB5 antibody
      • X box binding protein 1 antibody
      • X box binding protein 2 antibody
      • X-box-binding protein 1 antibody
      • XBP 1 antibody
      • XBP-1 antibody
      • XBP1 antibody
      • XBP1_HUMAN antibody
      • XBP2 antibody
      see all

    Anti-XBP1 antibody 画像

    • All lanes : Anti-XBP1 antibody (ab28715) at 1 µg/ml

      Lane 1 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate
      Lane 2 : Testis (Rat) Tissue Lysate
      Lane 3 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
      Developed using the ECL technique

      Performed under reducing conditions.

      Predicted band size : 33 kDa
      Observed band size : 35 kDa (why is the actual band size different from the predicted?)


      Exposure time : 8 minutes

    Anti-XBP1 antibody (ab28715) 使用論文

    ab28715 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab28715.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"