製品の概要

  • 製品名Anti-WWOX3 antibody
    WWOX3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to WWOX3
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C-terminal amino acids 368-396 of Human WWOX3 (Q9NZC7, NP_057457.1, NP_570607.1).

  • ポジティブ・コントロール
    • Mouse testis tissue lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)Purified through a Protein A column, followed by peptide affinity purification.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab123722 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 47 kDa.

ターゲット情報

  • 機能Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
  • 組織特異性Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.
  • 関連疾患Note=Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.
    Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:133239].
  • 配列類似性Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    Contains 2 WW domains.
  • ドメインThe WW 1 domain mediates interaction with TP53, and probably TP73, TFAP2C, LITAF and WBP1.
  • 翻訳後修飾Phosphorylated upon genotoxic stress. Phosphorylation of Tyr-33 regulates interaction with TP53, TP73 and MAPK8. May also regulate proapoptotic activity. Phosphorylation by TNK2 is associated with polyubiquitination and degradation.
    Ubiquitinated when phosphorylated by TNK2, leading to its degradation.
  • 細胞内局在Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus. Partially localizes to the mitochondria. Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1. Isoform 5 and isoform 6 may localize in the nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • D16S432E antibody
    • FOR antibody
    • FRA16D antibody
    • Fragile site FRA16D oxidoreductase antibody
    • HHCMA56 antibody
    • PRO0128 antibody
    • SCAR12 antibody
    • SDR41C1 antibody
    • short chain dehydrogenase/reductase family 41C member 1 antibody
    • WOX1 antibody
    • WW domain containing oxidoreductase antibody
    • WW domain containing protein WWOX antibody
    • WW domain-containing oxidoreductase antibody
    • wwox antibody
    • WWOX_HUMAN antibody
    see all

Anti-WWOX3 antibody 画像

  • Anti-WWOX3 antibody (ab123722) at 1/100 dilution + Mouse testis tissue lysate at 35 µg

    Predicted band size : 47 kDa

Anti-WWOX3 antibody (ab123722) 使用論文

ab123722 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab123722.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"