Wortmannin, PI3-kinase inhibitor (ab120148)
Key features and details
- PI3-kinase inhibitor
- CAS Number: 19545-26-7
- Purity: > 98%
- Soluble in DMSO to 50 mM and in ethanol to 5 mM
- Form / State: Solid
- Source: Penicillium funiculosum
製品の概要
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製品名
Wortmannin, PI3-kinase inhibitor -
製品の詳細
PI3-kinase inhibitor -
生理活性の詳細
Potent, selective and cell-permeable inhibitor of phosphatidylinositol-3-kinase (PI3-kinase) (IC50 ~ 3 nM)
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精製度
> 98% -
CAS 番号
19545-26-7 -
構造式
製品の特性
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体系名
(1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5,h]-2-h]-2-benzopyran-3,6,9-trione -
分子量
428.44 -
分子式
C23H24O8 -
PubChem 登録番号
312145 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 50 mM and in ethanol to 5 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC(=O)O[C@@H]4C[C@]5(C)C(=O)CC[C@H]5C=3C(=O)c2occ1C(=O)O[C@H](COC)[C@@](C)(c12)C=34 -
由来
Penicillium funiculosum
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研究分野
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- PI3K/Akt signaling
- PI3-kinase
- Inhibitors
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- PI3K/Akt signaling
- PI3-kinase
- Inhibitors
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- PI3K/Akt signaling
- PI3-kinase
- Inhibitors
- Biochemicals
- Research Area
- Obesity
- Signaling
- Signal transduction
- PI3K/Akt signaling
- PI3-kinase
- Inhibitors
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (15)
ab120148 は 15 報の論文で使用されています。
- Zhang MH & Liu J Cleavage stimulation factor 2 promotes malignant progression of liver hepatocellular carcinoma by activating phosphatidylinositol 3'-kinase/protein kinase B/mammalian target of rapamycin pathway. Bioengineered 13:10047-10060 (2022). PubMed: 35412944
- Lee JH et al. n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway. Int J Mol Sci 22:N/A (2021). PubMed: 34199295
- Chen S et al. Ginsenoside metabolite 20(S)-protopanaxadiol promotes neural stem cell transition from a state of proliferation to differentiation by inducing autophagy and cell cycle arrest. Mol Med Rep 22:353-361 (2020). PubMed: 32319663
- Martin-Gallausiaux C et al. Fusobacterium nucleatum Extracellular Vesicles Modulate Gut Epithelial Cell Innate Immunity via FomA and TLR2. Front Immunol 11:583644 (2020). PubMed: 33408714
- Gamero-Estevez E et al. Temporal Effects of Quercetin on Tight Junction Barrier Properties and Claudin Expression and Localization in MDCK II Cells. Int J Mol Sci 20:N/A (2019). PubMed: 31581662