製品の概要

  • 製品名Anti-WHSC1/NSD2 antibody
    WHSC1/NSD2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to WHSC1/NSD2
  • アプリケーション適用あり: IPmore details
    適用なし: WB
  • 種交差性
    交差種: Human
    交差が予測される動物種: Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region between residues 1315 and 1365 of Human WHSC1/NSD2 (NP_579877.1).

  • ポジティブ・コントロール
    • HeLa whole cell lysate

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab113258 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use at 2-10 µg/mg of lysate.
  • 追加情報Is unsuitable for WB.
  • ターゲット情報

    • 機能Probable histone methyltransferase (By similarity). May act as a transcription regulator that binds DNA and suppresses IL5 transcription.
    • 組織特異性Widely expressed.
    • 関連疾患Note=A chromosomal aberration involving WHSC1 is a cause of multiple myeloma tumors. Translocation t(4;14)(p16.3;q32.3) with IgH.
      Note=WHSC1 is located in the Wolf-Hirschhorn syndrome (WHS) critical region. WHS results from by sub-telomeric deletions in the short arm of chromosome 4. WHSC1 is deleted in every case, however deletion of linked genes contributes to both the severity of the core characteristics and the presence of the additional syndromic problems.
    • 配列類似性Belongs to the histone-lysine methyltransferase family. SET2 subfamily.
      Contains 1 AWS domain.
      Contains 1 HMG box DNA-binding domain.
      Contains 4 PHD-type zinc fingers.
      Contains 1 post-SET domain.
      Contains 2 PWWP domains.
      Contains 1 SET domain.
    • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 細胞内局在Cytoplasm and Nucleus. Chromosome.
    • Information by UniProt
    • 参照データベース
    • 別名
      • FLJ23286 antibody
      • IL5 promoter REII region binding protein antibody
      • KIAA1090 antibody
      • MGC176638 antibody
      • MMSET antibody
      • MMSET type II antibody
      • Multiple myeloma SET domain containing protein type III antibody
      • Multiple myeloma SET domain protein antibody
      • Multiple myeloma SET domain-containing protein antibody
      • NSD 2 antibody
      • NSD2 antibody
      • NSD2_HUMAN antibody
      • Nuclear SET domain-containing protein 2 antibody
      • Probable histone-lysine N-methyltransferase NSD2 antibody
      • Protein trithorax-5 antibody
      • REIIBP antibody
      • Trithorax/ash1 related protein 5 antibody
      • TRX5 antibody
      • TRX5 protein antibody
      • WHS antibody
      • Whsc1 antibody
      • Wolf Hirschhorn syndrome candidate 1 antibody
      • Wolf Hirschhorn syndrome candidate 1 protein antibody
      • Wolf-Hirschhorn syndrome candidate 1 protein antibody
      see all

    Anti-WHSC1/NSD2 antibody 画像

    • ab113258 at 6ug/mg of lysate detecting WHSC1/NSD2 by immunoprecipitation (lane 1). 1mg of HeLa whole cell lysate was used, 20% of immunoprecipitate was loaded. Lane 2: IgG control.

    Anti-WHSC1/NSD2 antibody (ab113258) 使用論文

    ab113258 has not yet been referenced specifically in any publications.

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