The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
追加情報IHC-P: 1/100 - 1/500.
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
機能Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.
配列類似性Belongs to the AAA ATPase family. Contains 1 UBZ-type zinc finger.
翻訳後修飾Sumoylated by SUMO1 and SUMO2/3.
細胞内局在Nucleus. Colocalizes with WRN in granular structures in the nucleus.