KLH conjugated synthetic peptide, correponding to a region from an internal region of the Human WHIP protein. The immunogen sequence shows 100% homology to Human WHIP (isoform 1) and WHIP2 (isoform 2).
Human Kidney tissue
保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
機能Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.
配列類似性Belongs to the AAA ATPase family. Contains 1 UBZ-type zinc finger.
翻訳後修飾Sumoylated by SUMO1 and SUMO2/3.
細胞内局在Nucleus. Colocalizes with WRN in granular structures in the nucleus.