製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to WDR58
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 144-193 (AGGDCQLHTM DLETGTFTRV LRGHTDYIHC LALRERSPEV LSGGEDGAVR) of human WDR58 (NP_077315).

  • ポジティブ・コントロール
    • Human fetal pancreas lysate

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    Purified by peptide affinity chromatography method.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab84900 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 38 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能
    Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and THOC4.
  • 配列類似性
    Belongs to the WD repeat THOC6 family.
    Contains 7 WD repeats.
  • Information by UniProt
  • 参照データベース
  • 別名
    • fSAP35 antibody
    • Functional spliceosome-associated protein 35 antibody
    • MGC2655 antibody
    • PSEC0006 antibody
    • THO complex 6 homolog antibody
    • THO complex subunit 6 homolog antibody
    • Thoc6 antibody
    • THOC6_HUMAN antibody
    • WD repeat containing protein 58 antibody
    • WD repeat domain 58 antibody
    • WD repeat-containing protein 58 antibody
    see all

画像

  • Anti-WDR58 antibody (ab84900) at 1 µg/ml (in 5% skim milk / PBS buffer) + human fetal pancreas lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 38 kDa
    Observed band size : 38 kDa

プロトコール

参考文献

ab84900 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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