製品の概要

  • 製品名Anti-WDR51A antibody
    WDR51A 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to WDR51A
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length protein of Human WDR51A

  • ポジティブ・コントロール
    • Transfected 293T cells.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein A purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab67698 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 40 kDa (predicted molecular weight: 45 kDa).

ターゲット情報

  • 機能Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Required for ciliogenesis.
  • 関連疾患Defects in POC1A are the cause of short stature, onychodysplasia, facial dysmorphism, and hypotrichosis (SOFT) [MIM:614813]. A syndrome characterized by severely short long bones, peculiar facies associated with paucity of hair, and nail anomalies. Growth retardation is evident on prenatal ultrasound as early as the second trimester of pregnancy, and affected individuals reach a final stature consistent with a height age of 6 years to 8 years. Relative macrocephaly is present during early childhood but head circumference is markedly low by adulthood. Psychomotor development is normal. Facial dysmorphism includes a long, triangular face with prominent nose and small ears, and affected individuals have an unusual high-pitched voice. Clinodactyly, brachydactyly, and hypoplastic distal phalanges and fingernails are present in association with postpubertal sparse and short hair. Typical skeletal findings include short and thick long bones with mild irregular metaphyseal changes, short femoral necks, and hypoplastic pelvis and sacrum. All long bones of the hand are short, with major delay of carpal ossification and cone-shaped epiphyses. Vertebral body ossification is also delayed. Note=Cells derived from affected individuals have abnormal mitotic mechanics with multipolar spindles, in addition to clearly impaired ciliogenesis.
  • 配列類似性Belongs to the WD repeat POC1 family.
    Contains 7 WD repeats.
  • 細胞内局在Cytoplasm > cytoskeleton > centrosome > centriole. Cytoplasm > cytoskeleton > cilium basal body. Component of both mother and daughter centrioles.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Pix2 antibody
    • POC1 centriolar protein homolog A (Chlamydomonas) antibody
    • POC1 centriolar protein homolog A antibody
    • Poc1a antibody
    • POC1A_HUMAN antibody
    • WD repeat containing protein 51A antibody
    • WD repeat domain 51A antibody
    • WD repeat-containing protein 51A antibody
    see all

Anti-WDR51A antibody 画像

  • All lanes : Anti-WDR51A antibody (ab67698) at 1/500 dilution

    Lane 1 : WDR51A transfected 293T cells lysate
    Lane 2 : non transfected lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 45 kDa
    Observed band size : 40 kDa (why is the actual band size different from the predicted?)

Anti-WDR51A antibody (ab67698) 使用論文

ab67698 has not yet been referenced specifically in any publications.

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